Sunday, November 16, 2014

Cancer Cells Can "Infect" Normal Neighbors

Cancer Cells Can "Infect" Normal Neighbors

Genetic material shed by tumors can get dumped into healthy cells and transform them
October 23, 2014 |By Heidi Ledford and Nature magazine
prostate cancer cells

Microscopic view of prostate cancer cells showing Schlafen-11 primarily in the nucleus.
Credit: National Cancer Institute
When a cancer cell throws out its trash, it can turn healthy neighbors into fellow tumor cells, researchers have found.
Many cells, including cancerous ones, shed thousands of tiny membrane-bound vesicles called exosomes that contain proteins, DNA and RNA. The process is thought to be a waste-management system, but it may also facilitate cell-to-cell communication: some of these vesicles can then merge with other cells and dump their payload inside.
In a study published online on October 23 in Cancer Cell, researchers show that when human breast-cancer exosomes can cause tumors when mixed with normal cells then injected into mice. The results could pave the way to finding markers to monitor the progression of cancer, and possibly even point to targets for therapies.
“It’s amazing — these vesicles were considered garbage cans,” says Khalid Al-Nedawi, a cancer researcher at McMaster University in Hamilton, Canada. “This paper really brings us closer to harnessing the potential of these tiny vesicles.”

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