Monday, April 20, 2015

The Real History of Vaccines

Vaccines (Part I): Jenner, Pasteur, and the Dawn of Scientific Medicine
 Miguel A. Faria, Jr., MD
Article Type: 
 Editor's Corner
 March/April 2000
Volume Number: 
Issue Number: 
With the issue of mandatory vaccination programs for infants and children, lines have been drawn in the sand. On one side, we find concerned parents, increasingly being supported by dissenting physicians and scientists troubled by the serious side effects of vaccines, which have, in fact, been reported with greater frequency, including serious neurological deficits and even death. Physicians on this side of the line have not only asked for more open data and information to the public, but question the statistics as it regards specifically risks veHippocrates of Kosrsus benefit studies, the need for adhering to the individual-based ethics and admonition of Hippocrates (photo, right) of first doing no harm, and allowance for more parental involvement and freedom of choice --- that is, the right of parents to refuse to give their children certain vaccines; and full informed consent for parents --- that is, complete disclosure of all pertinent information relating to vaccine safety and efficacy.
On the other side of the line, we find government bureaucrats, public health officials, central planners, and much of the organized medical establishment militating for a greater role of government in "developing immunization strategies," developing tracking databases, increasing medical surveillance, and accelerating the pace of vaccine development, as well as enlarging the scope of mandatory vaccine programs already in place, particularly for infants and pre-school children. This group is bolstered not only by the coercive power and financial coffers of the federal government but also by the new collectivist, utilitarian ethics of population-based medicine. Recently, this group has even invoked history and the past necessities of medical authorities for using a variety of public strategies which may at times infringe on individual liberty. On August 3, 1999, U.S. Surgeon General David Satcher reminded chairman Dan Burton (R-IN) and his House Government Reform Committee of the benefits of mass immunization in protecting society from such historical scourges as poliomyelitis, measles, tetanus, meningitis, and other pestilential diseases once dreaded by man. He reassured the committee that "serious side effects are rare and that the benefits of immunization more than outweigh any potential risks." He added that vaccines are to be considered among the safest and most effective medicines in man's armamentarium in the fight against diseases.
And so, with this introduction, perhaps we should take a retrospective look at the history of vaccination and touch upon the development of the germ theory of disease to which it's necessarily entwined.
For full paper:

Vaccines (Part II): Hygiene, Sanitation, Immunization, and Pestilential Diseases
 Miguel A. Faria, Jr., MD
Article Type: 
 Feature Article
 March/April 2000
Volume Number: 
Issue Number: 
Vaccines --- Kill or Cure?
As the controversial debate over mandatory vaccine policy heats up igniting passions, it is perhaps appropriate we summarize what is known about the manifest benefits of modern vaccines, not forgetting the tremendously salutary impact on health and longevity wrought about by better living conditions, hygiene and sanitation, in general, and the introduction and subsequent widespread use of antibiotics, in particular.
In Part I of this essay, we discussed the history of vaccinations, the advent of the germ theory of disease, and the ushering in of the dawn of scientific medicine.(1) In Part II, we will weave into this historic tapestry the more contemporary history behind some of the many infectious illnesses of the 20th century and revisit the story as to how they were eradicated. Only then can we arrive at today's reality over vaccine policy and reach the truth as to the best possible advice that should presently be given to individual patients.(2,3)
Vaccinating ChildrenOfficials at the CDC tell us vaccines are "90 percent safe and effective." And according to UNICEF, vaccines save the lives of at least 1.5 million children every year. Yet, parents are concerned, and increasingly, dissenting physicians are asking questions and breaking away from the heretofore monolithic medical ranks. Let's look at the big picture to avoid missing the forest for the trees.
Growing up, I thought deadly infectious diseases had been conquered long ago. Yet, in Cuba, I knew of a girl who died of diphtheria, and my father as a country doctor, diagnosed and treated a case of anthrax and another one of typhus. When I visited Haiti in 1975 as a medical student, I saw cases of tetanus and congenital syphilis. In 1982, while I was chief neurosurgical resident at Grady Memorial Hospital in Atlanta, Georgia, we had in our service, simultaneously, patients with Pott's Disease, miliary TB with renal involvement and cerebral tuberculoma (for which we were consulted as to possible removal), and tubercular meningitis (for which we were to implant a Rickham reservoir for CNS chemotherapy). Scrofula was the only "classical" TB case missing in our clinical service!
And with the advent of AIDS and other immune deficiency and immunosuppressed states, we have seen in the 1990s a resurgence of tuberculosis and other opportunistic, infectious diseases, e.g., toxoplasmosis, cytomegalovirus (CMV), etc. In my own practice, I treated patients with chronic fungal meningitis and bacterial subdural empyemas requiring surgical evacuation. So, infectious diseases are still with us, and so taking preventive public health measures is prudent in many circumstances when the public is at risk. With this in mind, let's look at some of these diseases that are specifically salient to our discussion, and try to separate the wheat from the chaff in the debate.
For the full paper:

How Big Pharma Invests in Politicians

Does Big Pharma Own America?

For full article please visit

Mitchell voted on SB 277 last week, which would make her in violation since SB 277 would bring financial gain to Merck who gave her money within 12 months of the vote.
Sen. Holly Mitchell
Sen. Holly Mitchell
Mitchell has been receiving direct funding from Merck as far back as 2010, as have other members of the State Senate Health Committee (see chart below) including  Sen. Andy Vidak. Vidak also received direct funds from Merck as recently as 2014.  Vidak was set to vote on the bill Wednesday as a member of the Education Committee, but becauseit was tabled he will vote privately next week. Voting on this bill could also put him inside the restricted 12-month period (click here to see the campaign donations).
Sen. Andy Vidak
Education Committee Chairman Carol Liu expressed a desire for religious exemption to be an option in California, after witnessing droves of parents of vaccine injured children show up at Wednesday’s hearing (click on the above link and start at 48:30 to hear). There were also educators, health professionals and constituents that came forward to let their voices be heard in opposition to the proposed legislation.  Liu gave Pan one week to re-tool and return for a private vote next week.
But the larger question remains: How did we get here in the first place?
In 1986 the U.S. Supreme Court ruled vaccines are “unavoidably unsafe.” The ruling allowed Big Pharma to be exempt from any responsibility of injury, and instead the Government set up a separate ‘court’ that pays Big Pharma’s bill for those who are either have a vaccine injured child or have a child who died as a result of vaccines.  To date, the government-sponsored Vaccine Injury Fund has paid out $3 billion in settlement costs to families.  Result? No Courts. You can’t sue a vaccine manufacturer if you are injured.
MERCK 2010 Campaign ContributionsThe next puzzle piece fell into place in the late ’90s. when the FCC deregulated its advertising policy allowing for pharmaceutical companies to market drugs direct-to-consumers (DTC marketing). That’s when the ‘ask your doctor’ commercials started showing up on television, which allows companies like Merck to market their drugs directly to children. Merck did exactly that with their controversial Gardasil vaccine, launching a fearcampaign on VH1 that targeted teenage girls directly to get  them to go to their parents and ask to get the shots. It worked.
It is also what has enabled Big Pharma to own the media, who in the age of the internet, are fighting for every advertising dollar they can get to stay alive. According to Robert Kennedy, Jr., Big Pharma is responsible for up to 70% of the advertising revenue on network television in non-election years and, as a result, major networks refuse to air the story. Result? No media.
So our courts are bought, our media is bought. What’s left?
Routine campaign practices: In 2014, Merck Pharmaceuticals spent $1 million plus on political donations made directly to candidates running for office across the United States. Those contributions follow a pattern of typically small, $1,000, $2,500, etc., mainly because they are direct and on the record.
But if you dig a little deeper, it turns out the indirect contributions are where things start to get more interesting. The real money is shuffled from hand-to-hand via third-party groups called political action committees (PACs).
For example, Merck gives $15k to the PAC Biotech Industrial Organization; the Biotech Industrial Organization turns around and gives $10k to the Democratic Governor’s Association.  The Democratic Party is the largest contributor to Sen. Pan’s campaigns ( PACs like, PhRMA (Amgen, Merck, Pfizer, Bristol-Myers Squibb, Eli Lilly, Novartis, Abbvie Inc.) regularly fund politician’s campaigns (see $54,000 & $6,000 contributions by PhRMA to California politicians in the chart above), but they do it in ways you and I might never suspect. Result? No politicians.
PhRMA hired 757 lobbyists in 15 years.
Merck gives ten times that and more in national grants at medical schools and universities, thereby sprinkling the money like a bread-crumb trail to up-and-coming doctors and researchers making sure they are bought before they even get out of medical school.
It gets worse.
Merck is the exclusive maker and manufacturer of 10 vaccines currently on the CDC schedule, the most controversial being Gardasil and the MMR.  (Gardasil is facing formal criminal complaints from Spain filed in August of last year. The story has yet to make headlines amongst major media outlets in the United States at the time of this post.)

Sunday, April 19, 2015

Time to Exonerate Andrew Wakefield

Peer Reviewed Papers Support Findings of Andrew Wakefield 
The following peer-reviewed papers support the findings of the original work by Wakefield and colleagues at the Royal Free Hospital in the UK:
1) Furlano R, Anthony A, Day R, Brown A, Mc Garvey L, Thomson M, et al. Colonic CD8 and T cell filtration with epithelial damage in children with autism. J Pediatr 2001;138:366-72.
 2) Torrente F., Machado N., Perez-Machado M., Furlano R., Thomson M., Davies S., Wakefield AJ, Walker-Smith JA, Murch SH. Enteropathy with T cell infiltration and epithelial IgG deposition in autism. Molecular Psychiatry. 2002;7:375-382.
 3) Ashwood P, Murch SH, Anthony A, Hayes C, Machado MP, Torrente F, Thomson MA, Heuschkel R, Wakefield AJ., Mucosal and peripheral blood lymphocyte cytokine profiles in children with regressive autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Gastroenterol. 2002;122 (Suppl):A617
4) Ashwood P, Anthony A, Torrente F, Wakefield AJ. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol. 2004;24(6):664-73.
5) Wakefield AJ., Puleston J. Montgomery SM., Anthony A., O’Leary J.J., Murch SH Entero-colonic encephalopathy, autism and opioid receptor ligands. Alimentary Pharmacology & Therapeutics. 2002;16:663-674
6) Wakefield AJ. The Gut-Brain Axis in Childhood developmental Disorders. Journal of Pediatric Gastroenterology and Nutrition. 2002;34:S14-S17
7) Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A, Murch SH, Wakefield AJ, O’Leary JJ., Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Molecular Pathology 2002;55:84-90
 8) Ashwood P, Anthony A, Pellicer AA, Torrente F, Wakefield AJ. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. Journal of Clinical Immunology, 2003;23:504-517.
9) Torrente F, Anthony A, Heuschkel RB, Thomson MA, Ashwood P, Murch SH. Focal-enhanced gastritis in regressive autism with features distinct from Crohn's and Helicobacter pylori gastritis. Am J Gastroenterol. 2004;99:598-605
10) Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J Neuroimmunol. 2006;173(1-2):126-34.
11) Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. Eur J Gastroenterol Hepatol. 2005 Aug;17(8):827-36.
The following two peer-reviewed papers from the Royal Free Hospital in the UK were withdrawn for political reasons, but the science remains valid and relevant
1) Wakefield AJ, Murch SM, Anthony A et al., Ileal- lymphoid- nodular Hyperplasia, Non- specific Colitis, and Pervasive Developmental Disorder in Children, The Lancet, 1998, 351(9103): 637– 41.
2) Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, Walker-Smith JA. Enterocolitis in children with developmental disorder. American Journal of Gastroenterology 2000;95:2285-2295.
The following peer-reviewed papers duplicate Dr. Wakefield’s original findings in five additional countries, including the US, Italy, Venezuela, Canada and Poland:
 1) Gonzalez, L. et al., Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with gastro-Intestinal Symptoms. Arch Venez Pueric Pediatr, 2005;69:19-25.
 2) Balzola, F., et al., Panenteric IBD-like disease in a patient with regressive autism shown for the first time by wireless capsule enteroscopy: Another piece in the jig-saw of the gut-brain syndrome? American Journal of Gastroenterology, 2005. 100(4): p. 979- 981.
 3) Balzola F et al . Autistic enterocolitis: confirmation of a new inflammatory bowel disease in an Italian cohort of patients. Gastroenterology 2005;128(Suppl. 2);A-303.
4) Krigsman A, Boris M, Goldblatt A, Stott C. Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms. Autism Insights. 2009;1:1–11.
5) Horvath K., Papadimitriou J.C., Rabsztyn A., Drachenberg C., Tildon J.T. 1999. Gastrointestinal abnormalities in children with autism. J. Pediatrics 135: 559-563.
6) Sabra S, Bellanti JA, Colon AR. Ileal lymphoid hyperplasia, non-specific colitis and pervasive developmental disorder in children. The Lancet 1998;352:234-5.
7) Sabra A, Hartman D, Zeligs BJ et al., Linkage of ileal-lymphoid-nodular hyperplasia (ILNH), food allergy and CNS developmental abnormalities: evidence for a non-IgE association, Ann Allergy Asthma Immunol, 1999;82:8
8) Galiatsatos P, Gologan A, Lamoureux E, Autistic enterocolitis: Fact or fiction? Can J Gastroenterol. 2009:23:95-98
9) Jarocka-Cyrta et al. Brief report: eosinophilic esophagitis as a cause of feeding problems in an autistic boy. The first reported case.J. Aut. Dev. Disord. Online July 10, 2010
The following articles support the importance of recognizing and treating gastrointestinal symptoms in autistic children:
 1)    Buie T, et al. Pediatrics. 2010 Jan;125 Suppl 1:S19-29.  Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs.
 2)    Buie T, et al.  Pediatrics.  2010 Jan;125 Suppl 1:S1-18.  Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report.
The following peer-reviewed papers provide further support for gastrointestinal disturbances involving the immune system in autism.
1) Jyonouchi H., Sun S., Lee H. 2001. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J. Neuroimmunol. 120(1-2):170-9
2) Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B. Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention. Neuropsychobiology. 2005;28:5177-85
3) Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier B. Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. J Pediatr.2005;146(5):605-10.
4) Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46(2):76-84.
5) Vojdani A, O'Bryan T, Green JA, McCandless J, Woeller KN, Vojdani E, Nourian AA, Cooper EL. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr. Neurosci. 2004;7:151-61.
6) Whiteley P, Haracopos D, Knivsberg AM, Reichelt KL, Parlar S, Jacobsen J, Seim A, Pedersen L, Schondel M, Shattock P. The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutr Neurosci. 2010;13(2):87-100.
7) Knivsberg AM, Reichelt KL, Høien T, Nødland M. A randomised, controlled study  of dietary intervention in autistic syndromes. Nutr Neurosci. 2002;5(4):251-61.
8) Balzola F, et al. Beneficial behavioural effects of IBD therapy and gluten/casein-free diet in an Italian cohort of patients with autistic enterocolitis followed over one year. Gastroenterology 2008;4:S1364.
9) Valicenti-McDermott M., McVicar K., Rapin I., et al., Frequency of Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders and Association with Family History of Autoimmune Disease. Developmental and Behavioral Pediatrics. 2006;27:128-136
10) Chen B, Girgis S, El-Matary W. Childhood Autism and Eosinophilic Colitis. Digestion 2010;18:127-129
11) Sandler R, Finegold SM., Bolte ER., et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol. 2000;15:429-435
 Dr Andrew Wakefield - Autism/Gut Connection
“Dr. Wakefield’s crucifixtion is a desperate well-orchestrated effort to restore faith in risky vaccinations that the majority of people worldwide no longer trust” -Dr. Len Horowitz

The headlines blasted around the world vilifying Dr. Wakefield should instead have been trumpeting the success enjoyed by the team of doctors at the Royal Free Hospital in London, the families of the kids who participated, and certainly the children themselves, when the treatments for their inflamed bowels resulted in amelioration of their symptoms of autism; when kids who hadn't been able to sleep through the night for months began getting a full night's sleep; when kids who hadn't spoken for months - or longer - again began speaking, and speaking with language usage commensurate with their age at the time, not at the age at which they'd stopped speaking! Thus demonstrating continued mental growth despite the outward appearance of absence, and when kids who'd lost emotional connection with their families once again began recognizing and bonding with their parents and siblings.

The Mythical ‘Debunking’ of Andrew Wakefield

Wednesday, April 15, 2015

The US Congress Should Investigate the CDC for the Vaccine Autism Link Cover Up

The Congressional Inquiry Into CDC Vaccine-Autism Link Cover Up Should Include:

The charges against CDC 

1. The two Verstreaten studies initially showing an RR of 7.62 (11.35 for ADD) reduced by Verstraeten and colleagues before calling in the experts in 2000 whereby one study was modified to 'no association' and published in Pediatrics. The other study showing an association of 7.62 lies unpublished as the Simpsonwood records were pried open by FOIA. 

2. The Vaccine Safety Datalink on which the Verstraeten study was based was partially destroyed and shipped out of the USA to keep it out of FOIA ambit after Dr Geier accessed the database to show the same association 

3. The Danish studies showing 'no association' found later to have been fabricated as the principal author Dr Poul Thorsen had pocketed a significant portion of the grant and is on the most wanted list of US Police. He faces a lifetime in jail after extradition. His university has sacked and disowned him. 

4. The DeStefano study is under a cloud after his CDC co-author Dr William Thompson has admitted large scale data manipulation. Original data handed over to Dr Brian Hooker found a 340% increase in afro-asian children following vaccinations. 

5. The CDC is yet to retract the fraudulent studies. 

The US Congress has actually questioned the CDC on many of these issues but the CDC is yet to reply and is trying to obfuscate the public with false reporting on the issue. The US Congress is still on the hunt and the next hearing is awaited. On 29th July 2015 Congressman Bill Posey has deposed before the US House of Representatives. In the meanwhile Whistleblower Thompson has detailed how papers detailing the vaccine-autism connection were destroyed by CDC scientists in 2002.


Evidence of Harm: Mercury in Vaccines and the Autism Epidemic: A Medical Controversy 

Update: Congressman’s Office In Possession of 100,000 CDC Whistleblower Documents?

Whistleblower Claims CDC Covered Up Data Showing Vaccine-Autism Link


Fugitive Profiles

OIG Fugitive: Poul Thorsen

Poul Thorsen
  • From approximately February 2004 until February 2010, Poul Thorsen executed a scheme to steal grant money awarded by the Centers for Disease Control and Prevention (CDC). CDC had awarded grant money to Denmark for research involving infant disabilities, autism, genetic disorders, and fetal alcohol syndrome. CDC awarded the grant to fund studies of the relationship between autism and the exposure to vaccines, the relationship between cerebral palsy and infection during pregnancy, and the relationship between developmental outcomes and fetal alcohol exposure.
  • Thorsen worked as a visiting scientist at CDC, Division of Birth Defects and Developmental Disabilities, before the grant was awarded.
  • The initial grant was awarded to the Danish Medical Research Council. In approximately 2007, a second grant was awarded to the Danish Agency for Science, Technology, and Innovation. Both agencies are governmental agencies in Denmark. The research was done by the Aarhaus University and Odense University Hospital in Denmark.
  • Thorsen allegedly diverted over $1 million of the CDC grant money to his own personal bank account. Thorsen submitted fraudulent invoices on CDC letterhead to medical facilities assisting in the research for reimbursement of work allegedly covered by the grants. The invoices were addressed to Aarhaus University and Sahlgrenska University Hospital. The fact that the invoices were on CDC letterhead made it appear that CDC was requesting the money from Aarhaus University and Sahlgrenska University Hospital although the bank account listed on the invoices belonged to Thorsen.
  • In April 2011, Thorsen was indicted on 22 counts of Wire Fraud and Money Laundering.
  • According to bank account records, Thorsen purchased a home in Atlanta, a Harley Davidson motorcycle, an Audi automobile, and a Honda SUV with funds that he received from the CDC grants.
  • Thorsen is currently in Denmark and is awaiting extradition to the United States.

Fraud at the CDC uncovered, 340% risk of autism hidden from public

Obama Grants Immunity to CDC Whistleblower on Measles Vaccine Link to Autism 

Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink (PDF 227 K) 
 2014 Sep 5;11(9):9156-70. doi: 10.3390/ijerph110909156.

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders.

Simpsonwood Transcripts:

Scientific Review of Vaccine Safety Datalink Information June 7-8, 2000 Simpsonwood Retreat Center Norcross, Georgia 

The US Department of Health Resources and Services Administration has already recognized autism as a secondary cause of vaccine injury as documented in the Update to the Vaccine Injury Table following the 2011 IOM report. They did reject Autism as a direct adverse effect of the MMR specifically, but in view of these revelations that may be revisited.

The CDC responded to these claims stating that they recognize this study showed an increased risk of autism from the MMR:

CDC Autism Whistleblower Admits Vaccine Study Fraud

BioMed Research International
Volume 2014 (2014), Article ID 247218, 8 pages

CDC Forced to Release Documents Showing They Knew Vaccine Preservative Causes Autism

Review Article

Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe

In the U.S. and Canada, doctors recommend 8 vaccines at 2, 4, and 6 months of age. These vaccines were tested individually but not in combination. No studies anywhere in the world were ever conducted to provide scientific evidence that infants are not subjected to synergistic toxicity from the simultaneous administration of 8 drugs. In fact, there is evidence to the contrary. As babies receive more vaccines concurrently, they are more likely to be hospitalized and die:
Many people have also lost trust in the organizations that are commissioned to oversee vaccine safety. For example, 15 years ago the CDC conducted a study that confirmed a link between thimerosal (mercury) in vaccines and autism. Infants that received vaccines with the highest quantities of thimerosal were nearly 8 times more likely to develop autism compared to infants that did not receive thimerosal-containing vaccines (RR = 7.6). Instead of publishing this study, the CDC quashed it. Here is the abstract:

Other studies provide additional evidence of scientific malfeasance with regard to some well-publicized studies purporting to show no link between vaccines and severe safety hazards. For example:

Florida Congressman Bill Posey: CDC Whistleblower Discloses Vaccine Deception 

Posey Again Batters CDC Over Vaccine Autism Coverup 

U.S. Citizens March on CDC Headquarters in Atlanta to Protest Vaccine Science Corruption - See more at:

Tuesday, April 14, 2015

Vaccine Strain Polio Viruses - Greatest Threat of Polio

Emerging form of poliovirus threatens hopes for eradication

by Erin Digitale
Emerging form of poliovirus threatens hopes for eradication

Circulating vaccine-derived polioviruses are "the biggest surprise" that scientists have encountered in their work to end polio, said Walter Orenstein, MD, lead author of a 2014 clinical report about  from the American Academy of Pediatrics and a professor of medicine at Emory University. The viruses "are genotypically vaccine, but phenotypically wild virus," Orenstein explained; in other words, they look genetically like the vaccine, but behave in nature like their wild counterparts.
How a mutated virus regains power
These vaccine-derived viruses are escapees. They start in the intestines of a tiny fraction of people who receive the oral . The  uses live, but attenuated, strains of poliovirus, meaning the pathogen has been altered to be harmless—or at least much less virulent. In about one in a million people, though, the attenuated poliovirus mutates in such a way that it regains its potency. Sometimes, it sickens the individual who got the vaccine, a problem known to doctors for decades.
What's come as a surprise, however, is that even if these mutated viruses fail to affect the person in whom they originate, they may escape into the environment in the individuals' feces and start infecting people like wild viruses do: In areas with poor sanitation systems, untreated sewage spreads the new viruses to others, who can become sickened. For instance, in Nigeria during the first nine months of 2014, 21 polio cases were caused by the circulating vaccine-derived viruses, compared to six cases from the wild virus, according to a report from the U.S. Centers for Disease Control and Prevention. In the same period, Pakistan had 22 cases from circulating vaccine-derived viruses and 170 from wild viruses, while Afghanistan had no cases from vaccine-derived viruses and nine from wild poliovirus, the CDC reported.
The risk is prompting public health experts to re-examine how best to protect children in developing countries from polio. For example, with a grant from the Bill & Melinda Gates Foundation, Maldonado is collecting data in communities in Mexico that are changing their polio-vaccination strategy.
"It's important to understand how we can phase out the live-virus vaccine, so that we can use the killed vaccine in the best way possible," Maldonado said, referring to a vaccination method that uses an injection of dead poliovirus. "We want not only to prevent circulation of natural polio, but also to understand how to prevent the viruses derived from the live vaccine from becoming the next source of paralysis in communities."
For more on Polio:

What About Polio?

Scientists, Mainstream Doctors Endorse Homeopathy - Not a Placebo!

Homeopathy is not a placebo science
Sunday, 12 April 2015 - 7:00am IST | Agency: dna | From the print edition

Scientists discuss research to address medication and vaccines for diseases like cancer, AIDS, swine flu and MDR-TB at world summit 
  • From left: Dr Abhay Chowdhary, Dr Kajaksha Ghosh, Dr Jayesh Bellare, Dr Alakpita Paranjpe and Dr Rajesh Shah at the conference
Contrary to popular belief, homeopathy is not a placebo science, said a group of eminent scientists at the World Homeopathy Summit being held in the city this weekend. It has been long believed that consuming homeopathic medicine has a psychological effect on the patient which leads to some of them getting cured. Busting this and other myths, scientists from Haffkine Institute in Parel, Bhabha Atomic Research Centre (BARC) at Chembur, Indian Institute of Technology (IIT-B) in Powai, and the Tata Institute of Fundamental Research (TIFR) shared their research at the summit, which has attracted scientists and doctors from different parts of the world including Italy, Brazil and Austria.

Critic claim that because homeopathy medicines are very highly diluted, they are merely believed to have a placebo effect. However, research by Dr Jayesh Bellare, head of department, Chemical Engineering, at IIT-B, and his team has proved that they do contain nano-particles of medicinal molecules. "While earlier it was thought that homeopathic medicines do not contain medicinal molecules, high resolution microscopes used in the IIT-B lab to observe the medicines found that the molecules do exist in nano sizes," said Dr Bellare.
Physicists at TIFR and BARC have detected the effect of energy particles in homeopathy using laser beams and electrical devices. Former BARC scientist and physicist, Dr Akalpita Paranjpe talked about an electrical device called 'Medical Analyser' which measures the effects of homeopathy medicines on a person's physiology. "We measured the heart rate of a person before and after administering homeopathic medicine Sulphur 200. We noticed that the body reacts to Sulphur 200 and that the ill person goes back to being normal after being administered the medicine," said Dr Paranjpe.
Dr Kanjaksha Ghosh, director, National Institute of Immunohaematology (NII) vouches for homeopathytherapy to cure bleeding disorder in haemophilia patients. "In a study conducted in Surat, Mumbai and Nasik, in 500 cases of haemophilic patients, internal bleeding has been stalled by administering homeopathic drugs," said Dr Ghosh. "There have been cases when the Factor 8 and 9 injections for haemophilia management have been unavailable or very expensive, one-year treatment can cost lakhs of rupees. Homeopathy drugs have proven effective in saving their lives," said Dr Ghosh.
Virologist Dr Abhay Chowdhury at Haffkine Institute said they are working on a homeopathy-based drug or a nosode, which is sourced from tuberculosis germs of multi-drug resistant TB patients. The nosode, which is hoped to improve the condition of TB patients, will undergo animal trials in the near future, said Dr Chowdhury.
Where is global research in homeopathy headed?
Austrian molecular biologist Dr Michael Frass and Indian scientist Dr Gaurisankar Sa have proved anti-cancer activities of homeopathy in laboratory experiments on cell lines extracted from the human body. Dr Gaurisankar also demonstrated the regression of cancer in rats after giving homeopathy medicines.
Swine flu may have preventive homeopathy, a Brazil researcher has found. Scientist from Brazil University conducted a study and proved the role of homeopathy medicine sourced from influenza virus itself to prevent the disease.
"Homeopathy is personalised medicine and homeopaths are the first technocrats in medicine in terms of use of computer software in early times for their analysis. MUHS is going to volunteer for meta-analysis in homeopathy. Human genes have a memory of health and diseases. Homeopathy helps to decode this information. Allopathy has scope only for curing only 40 per cent of diseases, which are mostly infectious and nutritional diseases," says Dr Arun Jamkar, Maharashtra University of Health Sciences (MUHS).

Natural Viral Infections Lead to Cancer Remission

Polio, Herpes, and Other Viruses Treat Cancer

Doctors have known about oncolytic viruses since the mid-1800s (since before they even really knew what a virus was), when they started reporting that tumors sometimes went into remission for a while following a bout of natural viral infection.
Sometimes it was infection with the measles, or the flu, and in at least one case, the chicken pox caused temporary regression of lymphatic leukemia.
In the 1950s and ’60s, the ability to propagate viruses in the lab instead of only in living organisms, made it possible for researchers to begin exploring the potential of oncolytic viruses to cure cancer.
 Polio,herpesmeasles, and mumps are among the so-called oncolytic viruses, which preferentially infect and kill cancer cells.  
Although the medical community has known about oncolytic viruses for over a century, it’s only now that their power is being harnessed for viable cancer treatments.