Friday, June 08, 2018

Vaccines making pathogens more dangerous.

Vaccines Are Pushing Pathogens to Evolve

Just as antibiotics breed resistance in bacteria, vaccines can incite changes that enable diseases to escape their control. Researchers are working to head off the evolution of new threats.
https://www.quantamagazine.org/how-vaccines-can-drive-pathogens-to-evolve-20180510/
Read and his colleagues are studying how the herpesvirus that causes Marek’s disease — a highly contagious, paralyzing and ultimately deadly ailment that costs the chicken industry more than $2 billion a year — might be evolving in response to its vaccine. Its latest vaccine, that is. Marek’s disease has been sickening chickens globally for over a century; birds catch it by inhaling dust laden with viral particles shed in other birds’ feathers. The first vaccine was introduced in 1970, when the disease was killing entire flocks. It worked well, but within a decade, the vaccine mysteriously began to fail; outbreaks of Marek’s began erupting in flocks of inoculated chickens. A second vaccine was licensed in 1983 in the hopes of solving the problem, yet it, too, gradually stopped working. Today, the poultry industry is on its third vaccine. It still works, but Read and others are concerned it might one day fail, too — and no fourth-line vaccine is waiting. Worse, in recent decades, the virus has become more deadly.

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